반응 #3506

반응 방정식

HCl

disulfate

2,7-diamino-6-phenylpyrido[2,3-d]pyrimidine

→

title compound

2-Amino-6-phenyl-pyrido[2,3-d]pyrimidin-7-ol

용매

water

반응 조건

후처리

1. 1
   온도the resulting mixture refluxed
2. 2
   온도The reaction mixture is cooled in an ice bath
3. 3
   여과filtered
4. 4
   세척the insoluble product washed with water

실험 절차

To a solution of 2 L of concentrated HCl and 1 L of water is added 300 g of the disulfate salt of 2,7-diamino-6-phenylpyrido[2,3-d]pyrimidine and the resulting mixture refluxed with stirring overnight. The reaction mixture is cooled in an ice bath, filtered, and the insoluble product washed with water, followed by ethanol to give 149 g of the title compound 2-amino-6-phenyl-pyrido[2,3-d]pyrimidin-7-ol, mp 390°-395° C. (darkens slowly above 350° C.).

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