반응 #350560

반응 방정식

Ethyl 3-ketohexanoate

hydrogen

→

racemic ethyl 3-hydroxyhexanoate

수율 85.0%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타the mixture was reacted
2. 2
   기타After removing the Raney nickel from the reactant
3. 3
   여과by filtration
4. 4
   농축the filtrate was concentrated
5. 5
   workup.DISTILLATIONdistilled under reduced pressure

실험 절차

Ethyl 3-ketohexanoate 50 g (0.32 mol), Raney nickel 10 g and tetrahydrofuran 500 ml were mixed, and the mixture was reacted with stirring in an autoclave at a temperature of 50° C. and a hydrogen pressure of 5 kg/cm2 for 30 hours. After removing the Raney nickel from the reactant by filtration, the filtrate was concentrated and distilled under reduced pressure to obtain racemic ethyl 3-hydroxyhexanoate 42 g (0.26 mol, 85% )

출처