반응 #350558

반응 방정식

NaOH

5-chloro-3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-ol

Thionylchloride

water

→

1,5-dichloro-3-(4-fluorophenyl)-2,3-dihydro-1H-inden

용매

ether

DMF

반응 조건

후처리

1. 1
   기타The organic phase was separated
2. 2
   건조dried (MgSO4)
3. 3
   기타evaporated

실험 절차

Thionylchloride (44 ml) was added dropwise with water-cooling to a solution of 5-chloro-3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-ol in ether (2L) with a catalytic amount of DMF (0.5 ml). Then the mixture was stirred for 2 hours at room temperature, poured into ice and neutralized with 9N NaOH. The organic phase was separated, dried (MgSO4) and evaporated to give 140 g of crude 1,5-dichloro-3-(4-fluorophenyl)-2,3-dihydro-1H-inden.

출처