반응 #3503

반응 방정식

water

potassium carbonate

chloromethylpropargyl ether

N-methoxybenzenesulfonamide

→

N-methoxy-N-propargyloxymethylbenzenesulfonamide

수율 85.6%

용매

acetonitrile

반응 조건

후처리

1. 1
   workup.ADDITIONwas added to the reaction solution
2. 2
   추출the mixture was extracted with ethyl acetate
3. 3
   기타The extract was dried
4. 4
   농축concentrated
5. 5
   기타purified by silica gel column chromatography

실험 절차

0.6 g of N-methoxybenzenesulfonamide was dissolved in 10 ml of acetonitrile, and 0.44 g of potassium carbonate and 0.34 g of chloromethylpropargyl ether were added thereto in this order. The mixture was stirred at room temperature for 4 hours. After completion of the reaction, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was dried, concentrated, and purified by silica gel column chromatography to obtain 0.7 g of N-methoxy-N-propargyloxymethylbenzenesulfonamide.

출처