반응 #3501

반응 방정식

N-methoxy-2,4-dichlorobenzamide

potassium carbonate

propargyl bromide

N,N-dimethylformamide

→

propargyl N-methoxy-2,4-dichlorobenzimidate

수율 29.8%

용매

water

반응 조건

후처리

1. 1
   workup.ADDITIONwas added to the reaction solution
2. 2
   추출the mixture was extracted with ethyl acetate
3. 3
   기타The extract was dried
4. 4
   농축concentrated
5. 5
   기타purified by silica gel column chromatography

실험 절차

1.0 g of N-methoxy-2,4-dichlorobenzamide, 0.75 g of potassium carbonate and 0.65 g of propargyl bromide were added to 10 ml of N,N-dimethylformamide, and the mixture was stirred for 3 hours. After completion of the reaction, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was dried, concentrated and purified by silica gel column chromatography to obtain 0.35 g of propargyl N-methoxy-2,4-dichlorobenzimidate.

출처