반응 #3490

반응 방정식

KOH

m-aminoacetophenone

2-amino-4-chloro-6-methylpyrimidine

HCl

→

4-(3-acetylphenyl)amino-2-amino-6-methylpyrimidine

수율 78.5%

용매

water

반응 조건

후처리

1. 1
   온도heated
2. 2
   온도at reflux for 1 hour
3. 3
   기타gave a light buff solid, which
4. 4
   여과was filtered out
5. 5
   기타dried

실험 절차

Compound No. 15: A suspension of m-aminoacetophenone (2.7 g) and 2-amino-4-chloro-6-methylpyrimidine (2.87 g) in 40 mL water was treated with 1.7 mL concentrated HCl and heated at reflux for 1 hour. Addition of 40 mL 1N KOH gave a light buff solid, which was filtered out and dried to give 3.8 g 4-(3-acetylphenyl)amino-2-amino-6-methylpyrimidine, mp 196°-98° C.

출처