반응 #348385
ord-e42bef5d4dd8458b8cd112224d2d9d0c
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타The organic phase is separated
- 2세척washed with water
- 3건조dried over sodium sulphate
- 4기타evaporated
실험 절차
A solution of 116 g of p-chlorocinnamyl bromide in 500 ml of methylene chloride is added dropwise with stirring to a mixture of 42 g of 3-methylamino-propionitrile and 8.9 g of benzyl-tri-(n-butyl)ammonium bromide in 1 liter of methylene chloride and 500 ml of 2 N sodium hydroxide solution at room temperature and under a nitrogen atmosphere, and the emulsion stirred for 65 hours at room temperature. The organic phase is separated, washed with water, dried over sodium sulphate and evaporated to yield 3-[N-(p-chlorocinnamyl)-methylamino]-propionitrile. M.P. 143° [hydrogen oxalate form]