반응 #347422

반응 방정식

(l)-pyroglutamic acid

hydroquinone

→

crystals

4-HYDROXYPHENOL (L)-PYROGLUTAMATE

용매

water

반응 조건

후처리

1. 1
   기타is lowered to 50°
2. 2
   추출extracted with ethyl acetate (3×400 ml)
3. 3
   기타A crude product is thus prepared which
4. 4
   기타is purified

실험 절차

129 g (1 mol) of (l)-pyroglutamic acid and 110 g (1 mol) of hydroquinone are intimately mixed, the mixture is stirred at 175° under a stream of nitrogen for 18 hours, the temperature is lowered to 50° and the mixture is diluted with water (300 ml) and extracted with ethyl acetate (3×400 ml). A crude product is thus prepared which is purified by being made into a paste twice with ethyl acetate (250 ml) to give the title derivative in the form of crystals melting at 179°/82°. In TLC, the product shows a single spot of Rf(i)=0.33.

출처