반응 #347375

반응 방정식

product

1-Methyl-3-{N-[β-(4-hydroxyphenyl)ethyl]}carbamoylpyridinium iodide

sodium bicarbonate

N2

sodium dithionite

→

1-Methyl-3-{N-[β-(4-hydroxyphenyl)ethyl]}carbamoyl-1,4-dihydropyridine

용매

water

반응 조건

후처리

1. 1
   workup.ADDITIONwere gradually added to the mixture
2. 2
   추출extracted twice
3. 3
   추출The combined extract
4. 4
   세척was washed with water
5. 5
   건조dried over anhydrous Na2SO4
6. 6
   workup.DISTILLATIONdistilled on rotovap
7. 7
   기타Yield

실험 절차

To an ice cold solution of 1.15 g (3 mmol) of the product of Example 27 in 200 ml of deaerated water, 1.5 g (18 mmol) sodium bicarbonate were added. While the mixture was bubbled with N2 gas, 2.09 g (12 mmol) of sodium dithionite were gradually added to the mixture. The mixture was stirred under N2 for 1 hr and then extracted twice, each with 100 ml of ethyl acetate. The combined extract was washed with water, dried over anhydrous Na2SO4 and distilled on rotovap. Yield, 0.38 g (50%) of yellowish semisolid which reduced alcoholic AgNO3TS instantaneously. (PMR as expected.)

출처