반응 #347362

반응 방정식

3-Benzoylpropionic acid

LiAlH4

H2O

→

6a

수율 80.0%

1-Phenyl-butane-1,4-diol

수율 80.0%

용매

THF

반응 조건

후처리

1. 1
   기타THF was evaporated
2. 2
   workup.ADDITIONDiethylether and HCl (2M) was added
3. 3
   추출The aqueous layer was extracted with diethylether
4. 4
   세척the combined organic layers were washed with H2O, aqueous NaHCO3 (saturated) and H2O
5. 5
   기타Drying
6. 6
   여과(MgSO4), filtration and evaporation

실험 절차

3-Benzoylpropionic acid 11a dissolved in THF was reacted with LiAlH4 according to the general procedure. The following workup procedure was used: H2O was added and THF was evaporated. Diethylether and HCl (2M) was added. The aqueous layer was extracted with diethylether and the combined organic layers were washed with H2O, aqueous NaHCO3 (saturated) and H2O. Drying (MgSO4), filtration and evaporation gave 80% yield of 6a. 1H-NMR: 7.35-7.22 (m, 5H, Ar--H); 4.70 (t, 1H, CH--OH); 3.64 (t, 2H, CH2OH); 3.10 (brs, 1H, CH--OH); 2.60 (brs, 1H, CH2 --OH); 1.84 (q, 2H, CH2 --CHOH); 1.72-1.61 (m, 2H, CH2CH2OH).

출처