반응 #346839

반응 방정식

dimethylformamide

3-phenylpropyl thiol

p-fluoroacetophenone

potassium carbonate

→

p-(3-phenylpropylthio)acetophenone

용매

water

반응 조건

후처리

1. 1
   온도reflux temperature for approximately 24 hours
2. 2
   온도The reaction mixture is cooled
3. 3
   추출extracted with methylene chloride
4. 4
   세척The extract is washed with water
5. 5
   건조a solution of 2 N sodium hydroxide, dried over anhydrous sodium sulfate
6. 6
   기타evaporated in vacuo
7. 7
   기타The residue is recrystallized from isopropyl alcohol

실험 절차

A mixture of 174.6 grams (1.15 mole) of 3-phenylpropyl thiol, 158.8 grams (1.15 mole) of p-fluoroacetophenone and 158.8 grams (1.15 mole) of potassium carbonate in 500 ml. of dry dimethylformamide is stirred at its reflux temperature for approximately 24 hours. The reaction mixture is cooled, water added and extracted with methylene chloride. The extract is washed with water, a solution of 2 N sodium hydroxide, dried over anhydrous sodium sulfate and evaporated in vacuo. The residue is recrystallized from isopropyl alcohol to yield the desired p-(3-phenylpropylthio)acetophenone having a m.p. of 76°-8° C.

출처