반응 #346765

반응 방정식

water

aluminium chloride

5-(4-Chlorobenzoyl)pentanoyl chloride

ferrocene

→

5-(4-chlorobenzoyl)pentanoyl ferrocene

용매

methylene chloride

반응 조건

후처리

1. 1
   기타The organic layer was separated
2. 2
   추출The aqueous layer was extracted with methylene chloride
3. 3
   세척the combined organic fractions were washed with water
4. 4
   건조dried (magnesium sulphate)
5. 5
   기타evaporated
6. 6
   기타to yield a brown solid
7. 7
   기타This was recrystallized from petroleum ether (60°-80°)

실험 절차

5-(4-Chlorobenzoyl)pentanoyl chloride (5.2g; 0.02 mole) in methylene chloride (100 ml) and ferrocene (3.75g; 0.02 mole) were stirred at 0.5° and aluminium chloride (2.7g; 0.02 mole) was added slowly over 0.5 hr. The mixture was stirred at 0.5° for 1.5 hr then water was added. The organic layer was separated. The aqueous layer was extracted with methylene chloride and the combined organic fractions were washed with water, dried (magnesium sulphate) and evaporated to yield a brown solid. This was recrystallized from petroleum ether (60°-80°) to yield pure 5-(4-chlorobenzoyl)pentanoyl ferrocene; 3.23g (40%); mp 103°-106°.

출처