반응 #346449

반응 방정식

2,3-Epoxypropyl isopropyl ether

sodium hydride

n-dodecylthiol

→

1-(n-dodecylthio)-3-isopropoxy-2-propanol

용매

tetrahydrofuran

tetrahydrofuran

반응 조건

후처리

1. 1
   기타formed by the addition of 50 mg
2. 2
   기타After approximately 4 hours the solvent is removed from the reaction mixture and 20 ml
3. 3
   workup.ADDITIONof water is added to the residue
4. 4
   추출The resultant aqueous mixture is extracted with ether
5. 5
   세척the ether extracts washed with water
6. 6
   건조dried over magnesium sulfate
7. 7
   기타evaporated

실험 절차

2,3-Epoxypropyl isopropyl ether (1.16 g.) in several ml. of dry tetrahydrofuran is added to a stirred suspension formed by the addition of 50 mg. of sodium hydride (56% dispersion in mineral oil) to 2.2 g. 8. of n-dodecylthiol in 50 ml. tetrahydrofuran. The mixture is then stirred at 60° C. After approximately 4 hours the solvent is removed from the reaction mixture and 20 ml. of water is added to the residue. The resultant aqueous mixture is extracted with ether and the ether extracts washed with water, dried over magnesium sulfate and evaporated to yield 1-(n-dodecylthio)-3-isopropoxy-2-propanol.

출처