반응 #346445

반응 방정식

lithium p-aminosalicylate

sodium p-aminosalicylate

potassium p-aminosalicylate

methyl chloride

menthyl bromide

menthyl iodide

para-aminosalicylic acid

→

menthyl-para-aminosalicylate

반응 조건

후처리

1. 1
   온도cooled to room temperature
2. 2
   여과filtered
3. 3
   기타to crystallize in an ice-chest

실험 절차

One-tenth mol of an alkali metal salt of para-aminosalicylic acid as for example, sodium-p-aminosalicylate, potassium-p-aminosalicylate or lithium-p-aminosalicylate, is dissolved in 300 ml. of alcohol and to this is added exactly one-tenth mol of a menthyl halogen salt as for example, methyl chloride, menthyl bromide or menthyl iodide. The mixture is stirred and 0.5 gms. of freshly precipitated silver hydroxide is added as a catalyst. The mixture is warmed to 50° C. for a period of at least two hours, cooled to room temperature and filtered. The filtrate is set aside to crystallize in an ice-chest and menthyl-para-aminosalicylate is obtained as a white crystalline substance melting at 187° C. to 189° C. The compound is insoluble in water but soluble in alcohol, benzene and chloroform.

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