반응 #3463

반응 방정식

1-([1,1'-biphenyl]-2-ylmethyl)-2-ethyl-4-methoxy-1H-indole

Cl2

→

1-([1,1'-biphenyl]-2-ylmethyl)-2-ethyl-4-hydroxy-1H-indole

수율 69.3%

용매

BBr3

반응 조건

후처리

1. 1
   기타The crude product was chromatographed on silica gel
2. 2
   세척eluted with 20% EtOAc/hexane

실험 절차

By the method used in Example 1, Part D, 911 mg (2.6 mmol) of 1-([1,1'-biphenyl]-2-ylmethyl)-2-ethyl-4-methoxy-1H-indole was O-demethylated by treating it with 10 mL of 1M BBr3 /CH2 Cl2. The crude product was chromatographed on silica gel and eluted with 20% EtOAc/hexane to give 590 mg (69% yield) of 1-([1,1'-biphenyl]-2-ylmethyl)-2-ethyl-4-hydroxy-1H-indole as an oil.

출처