반응 #345967

반응 방정식

2,4-dimethyl-1,5-di-(3,3-dimethylnorborn-2-yl)-3-pentanone

4-aminomethylpiperidine

hydrogen

→

4-[2,4-dimethyl-1,5-di-(3,3-dimethylnorborn-2-yl)-3-pentylaminomethyl]piperidine

용매

ethanol

반응 조건

후처리

1. 1
   여과platinum catalyst is filtered off
2. 2
   기타the ethanol removed under reduced pressure
3. 3
   workup.DISSOLUTIONThe residual oil is dissolved in ether
4. 4
   세척the ether solution washed several times with water
5. 5
   기타to remove the excess 4-aminomethylpiperidine
6. 6
   건조The ether extracts are dried over anhydrous sodium sulfate
7. 7
   농축concentrated under vacuum

실험 절차

A mixture of 2,4-dimethyl-1,5-di-(3,3-dimethylnorborn-2-yl)-3-pentanone (g., 0.1 mole) and 4-aminomethylpiperidine (34.2 g., 0.3 mole) ml. ethanol is hydrogenated with PtO2 at room temperature and 40 psi hydrogen pressure. The 2.5 g. platinum catalyst is filtered off and the ethanol removed under reduced pressure. The residual oil is dissolved in ether and the ether solution washed several times with water to remove the excess 4-aminomethylpiperidine. The ether extracts are dried over anhydrous sodium sulfate and concentrated under vacuum to leave 4-[2,4-dimethyl-1,5-di-(3,3-dimethylnorborn-2-yl)-3-pentylaminomethyl]piperidine.

출처