반응 #345931

ord-57b8f6f76b984b2194a9a2e8c3de0183

반응 방정식

CNC(=NCCSCc1[nH]cnc1C)NO.Cl.Cl
isothiourea dihydrochloride
CNC(=NCCSCc1[nH]cnc1C)NO.Cl.Cl
N-Hydroxy-N'-methyl-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine dihydrochloride
NOc1ccccc1
phenoxyamine
Cc1nc[nH]c1CSCCN=C(N)N(O)CCSCc1[nH]cnc1C.Cl.Cl.Cl
( ii )
Cc1nc[nH]c1CSCCN=C(N)N(O)CCSCc1[nH]cnc1C.Cl.Cl.Cl
N-Hydroxy-N,N"-bis[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine trihydrochloride
→
CNC(=NCCSCc1[nH]cnc1C)NOc1ccccc1.Cl.Cl
title product
CNC(=NCCSCc1[nH]cnc1C)NOc1ccccc1.Cl.Cl
N-Methyl-N'-phenoxy-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine dihydrochloride

반응물

CNC(=NCCSCc1[nH]cnc1C)NO.Cl.Cl
isothiourea dihydrochloride
CNC(=NCCSCc1[nH]cnc1C)NO.Cl.Cl
N-Hydroxy-N'-methyl-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine dihydrochloride
NOc1ccccc1
phenoxyamine
Cc1nc[nH]c1CSCCN=C(N)N(O)CCSCc1[nH]cnc1C.Cl.Cl.Cl
( ii )
Cc1nc[nH]c1CSCCN=C(N)N(O)CCSCc1[nH]cnc1C.Cl.Cl.Cl
N-Hydroxy-N,N"-bis[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine trihydrochloride

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Reaction of the isothiourea dihydrochloride produced by Example 1 (i) with phenoxyamine by the procedure of Example 1 (ii) gave the title product.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US04034101uspto-grants-1977_07