반응 #345691

반응 방정식

phosgene

5-cyclopropyl-2-amino-1,3,4-thiadiazole

→

5-Cyclopropyl-1,3,4-thiadiazol-2-yl Isocyanate

용매

ethyl acetate

ethyl acetate

반응 조건

후처리

1. 1
   기타equipped with a mechanical stirrer
2. 2
   기타resulting in the formation of a precipitate
3. 3
   기타The reaction mixture was then purged with nitrogen gas
4. 4
   기타to remove unreacted phosgene
5. 5
   여과The purged mixture was filtered
6. 6
   기타to recover the desired product 5-cyclopropyl-1,3,4-thiadiazol-2-yl isocyanate dimer

실험 절차

A saturated solution of phosgene in ethyl acetate (100 ml) was charged into a glass reaction vessel equipped with a mechanical stirrer. A slurry of 5-cyclopropyl-2-amino-1,3,4-thiadiazole (6 grams) in ethyl acetate (100 ml) was added to the reaction vessel, and the resulting mixture was stirred for a period of about 16 hours, resulting in the formation of a precipitate. The reaction mixture was then purged with nitrogen gas to remove unreacted phosgene. The purged mixture was filtered to recover the desired product 5-cyclopropyl-1,3,4-thiadiazol-2-yl isocyanate dimer.

출처