반응 #345626

반응 방정식

hydrochloric acid

lithium diisopropyl amide

(-)-2-norbornanone

allyl bromide

→

3-allyl-2-norbornanone

용매

tetrahydrofuran hexane

tetrahydrofuran

tetrahydrofuran

반응 조건

후처리

1. 1
   workup.STIRRINGthe mixture was stirred at -20° C. for 30 minutes
2. 2
   온도the temperature of the mixture was raised to room temperature
3. 3
   workup.STIRRINGthe mixture was stirred for one hour
4. 4
   추출the mixture was extracted with toluene (50 ml×4)
5. 5
   세척The extract was washed with successive, saturated sodium bicarbonate solution, water, saturated sodium chloride (each 50 ml), and
6. 6
   건조dried over anhydrous magnesium sulfate
7. 7
   여과The solution was filtered
8. 8
   workup.DISTILLATIONthe solvent was distilled off

실험 절차

To 3.4 ml (6.8 mmol) of a 2M solution of lithium diisopropyl amide in tetrahydrofuran-hexane, 1 ml of a solution of 500 mg (4.54 mmol) of (-)-2-norbornanone in tetrahydrofuran was added dropwise at -40° C., and the mixture was stirred at -20° C. for 10 minutes. Then, 1 ml of a solution of 540 mg (4.46 mmol) of allyl bromide in tetrahydrofuran was added dropwise, the mixture was stirred at -20° C. for 30 minutes, the temperature of the mixture was raised to room temperature, and the mixture was stirred for one hour. On ice cooling, the reaction mixture was poured into 20 ml of 1N hydrochloric acid, and the mixture was extracted with toluene (50 ml×4). The extract was washed with successive, saturated sodium bicarbonate solution, water, saturated sodium chloride (each 50 ml), and dried over anhydrous magnesium sulfate. The solution was filtered, and the solvent was distilled off to obtain 980 mg of crude 3-allyl-2-norbornanone. The product was purified by distillation, and 550 mg (3.66 mmol) of (-)-exo-3-allyl-2-norbornanone was obtained. Yield: 81%.

출처