반응 #345555

반응 방정식

phenyl cyanamide

1,2-epoxy butane

potassium carbonate

→

desired product

2-Imino-3-phenyl-5-ethyl-1,3-oxazolidine

용매

methyl ethyl ketone

반응 조건

후처리

1. 1
   기타In a flask were combined
2. 2
   여과It was then filtered
3. 3
   기타the methyl ethyl ketone removed in vacuo
4. 4
   기타The solids recovered from the filter
5. 5
   추출were extracted with acetone
6. 6
   workup.DISSOLUTIONThe combined solids were dissolved in water
7. 7
   기타The solvents were removed in vacuo
8. 8
   기타producing

실험 절차

In a flask were combined 3.0 grams (g) (25.4 mmol) phenyl cyanamide, 1.83 g (25.4 mmol) 1,2-epoxy butane, 3.51 g (25.4 mmol) potassium carbonate and 50 milliliters (ml) methyl ethyl ketone. The mixture was stirred overnight under a nitrogen blanket at room temperature. It was then filtered and the methyl ethyl ketone removed in vacuo. The solids recovered from the filter were extracted with acetone and combined with the residue from the main portion. The combined solids were dissolved in water and extraced with 15% isopropanol in chloroform. The solvents were removed in vacuo producing 2.30 g (48% of theoretical yield) of the desired product. Spectroscopic analysis confirmed the structure of the desired product. No type II product was detected.

출처