반응 #344866

반응 방정식

lithium diisopropylamide

2,6-difluoropyridine

N,N-dimethylethyleneurea

2-(4'-propylbicyclohexyl-4-yl)-1-iodoethane

→

2-(4'-propylbicyclohexyl-4-yl)-1-(2,6-difluoropyridine-3-yl)ethane

용매

THF hexane

THF

반응 조건

후처리

1. 1
   기타give the pure product

실험 절차

A solution of 0.02 mol of lithium diisopropylamide in THF/hexane (prepared analogously to Example 1) is added dropwise at 25° C. to a mixture of 0.2 mol of 2,6-difluoropyridine, 0.02 mol of N,N-dimethylethyleneurea, 0.02 mol of 2-(4'-propylbicyclohexyl-4-yl)-1-iodoethane and 25 ml of THF. Stirring for 1.5 hours and workup as described in Example 1 give the pure product.

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