반응 #3444

반응 방정식

1-([1,1'-biphenyl]-4-ylmethyl)-4-methoxy-2-methyl-1H-indole

BBr3

Cl2

→

1-([1,1'-biphenyl]-4-ylmethyl)-4-hydroxy-2-methyl-1H-indole

수율 77.4%

반응 조건

실험 절차

By the method used in Example 1, Part D, 1.3 g (4.0 mmol) of 1-([1,1'-biphenyl]-4-ylmethyl)-4-methoxy-2-methyl-1H-indole was O-demethylated by treating it with 16 mL of 1M BBr3 /CH2 Cl2 to give 970 mg (77% yield) of crude 1-([1,1'-biphenyl]-4-ylmethyl)-4-hydroxy-2-methyl-1H-indole.

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