반응 #344002

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5-chloro-1,2,4-triazolo[4,3-c]quinazoline

5-cyclopropyl-3-isocyanomethyl-1,2,4-oxadiazole

potassium tert-butoxide

→

title compound

5-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-imidazo[1,5-a]-1,2,4-triazolo[4,3-c]quinazoline

용매

DMF

DMF

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후처리

1. 1
   기타at 10° C.
2. 2
   기타to rise to room temperature
3. 3
   여과After 1/2 h the mixture was filtered
4. 4
   세척the filter cake washed with water and finally with ether
5. 5
   기타dried

실험 절차

To a stirred slurry of 5-chloro-1,2,4-triazolo[4,3-c]quinazoline (3.5 g, 17 mmol) in 40 ml of dry DMF at 10° C. was first added 5-cyclopropyl-3-isocyanomethyl-1,2,4-oxadiazole (purity 80%, 3.4 g, 18 mmol) and then a solution of potassium tert-butoxide (2.55 g, 23 mmol) in 40 ml of DMF, allowing the temperature to rise to room temperature. After 1/2 h the mixture was filtered and the filter cake washed with water and finally with ether and dried, giving the title compound as colorless crystals, m.p. 308°-314° C.

출처