반응 #343979

반응 방정식

DL-2-hydroxycaproic acid

decyl alcohol

→

clear colorless liquid

수율 49.0%

Decyl 2-Hydroxyhexanoate

수율 49.0%

용매

반응 조건

후처리

1. 1
   기타water collected as the reaction
2. 2
   세척by washing three times with 50 ml saturated sodium bicarbonate solution
3. 3
   기타The organic layer was collected
4. 4
   건조dried over magnesium sulfate
5. 5
   기타Excess decyl alcohol was removed by high vacuum distillation

실험 절차

A 50 ml one neck round bottom flask equipped with a Dean Stark trap, condenser and a nitrogen inlet/outlet was charged with 5.0 g (0.038 moles) DL-2-hydroxycaproic acid, 23.95 g (0.151 moles) decyl alcohol, and 0.019 g sulfuric acid. The reactants were heated to 140° C. for 8 hours and water collected as the reaction proceeded. The acid was neutralized by washing three times with 50 ml saturated sodium bicarbonate solution. Approximately 50 ml ether was needed to break the emulsion. The organic layer was collected and dried over magnesium sulfate. Excess decyl alcohol was removed by high vacuum distillation to yield 4.34 g (49% yield) of clear colorless liquid. According to GC the product is 95.74% pure.

출처