반응 #343964

반응 방정식

(E)-2-carbamoylvinyl (tri-n-butyl)tin

4-nitrobenzyl (5R,6S)-2-oxo-6-((1R)-1-hydroxyethyl) -1-carbapenam-3-carboxylate

diisopropylethylamine

tri(2-furyl)phosphine

trifluoromethanesulfonic anhydride

→

title compound

수율 34.3%

4-Nitrobenzyl (5R,6S)-2-((E)-2-carbamoylvinyl)-6-((1R)-1-hydroxyethyl) -1-carbapen-2-em-3-carboxylate

수율 34.3%

용매

N-methylpyrrolidinone

ethyl acetate

acetonitrile

ethyl acetate

반응 조건

후처리

1. 1
   세척the organic layer was washed with saturated aqueous sodium bicarbonate
2. 2
   건조After the extract was dried over anhydrous magnesium sulfate
3. 3
   기타the solvent was removed
4. 4
   기타the next reaction
5. 5
   기타without purification
6. 6
   workup.STIRRINGthe mixture was stirred for 2 hours at room temperature
7. 7
   세척the organic layer was washed with water
8. 8
   건조After the extract was dried over anhydrous magnesium sulfate
9. 9
   기타the solvent was removed
10. 10
    기타The residue was purified by silica gel column chromatography (elution with methanol-chloroform system)

실험 절차

Under a nitrogen atmosphere, to a solution of 128 mg (0.367 mmol) of 4-nitrobenzyl (5R,6S)-2-oxo-6-((1R)-1-hydroxyethyl) -1-carbapenam-3-carboxylate in acetonitrile (3ml) was added 0.065 ml (0.37 mmol) of diisopropylethylamine at -45° C., followed by 0.062 ml (0.37 mmol) of trifluoromethanesulfonic anhydride, and the mixture was stirred at -40°-30° C. for 30 minutes. To the reaction mixture was added ethyl acetate (3 ml), and the organic layer was washed with saturated aqueous sodium bicarbonate followed by saturated aqueous sodium chloride. After the extract was dried over anhydrous magnesium sulfate, the solvent was removed. The residual triflate was used the next reaction without purification. To this crude product was added 113 mg (0.83 mmol) of zinc chloride, 5.3 mg (0.0091 mmol) of bis(benzylideneacetone)palladium(0), and 4.4 mg (0.0185 mmol) of tri(2-furyl)phosphine. Under a nitrogen atmosphere, a solution of 157 mg (0.436 mmol) of (E)-2-carbamoylvinyl (tri-n-butyl)tin in N-methylpyrrolidinone (6 ml) was added, and the mixture was stirred for 2 hours at room temperature. To the reaction mixture was added ethyl acetate, and the organic layer was washed with water followed by saturated aqueous sodium chloride. After the extract was dried over anhydrous magnesium sulfate, the solvent was removed. The residue was purified by silica gel column chromatography (elution with methanol-chloroform system) to give 50.5 mg (yield: 34.3 %) of the title compound.

출처