반응 #343575

반응 방정식

2-benzyl-2,3-dihydrobenzofuran

bromine

→

desired compound

수율 38.5%

2-Benzyl-5-bromo-2,3-dihydrobenzofuran

수율 38.5%

용매

carbon tetrachloride

carbon tetrachloride

반응 조건

후처리

1. 1
   세척washed with water, sodium bicarbonate solution, and water again
2. 2
   기타The solvent was then evaporated
3. 3
   기타to afford 2.5 g of crude product which
4. 4
   기타was purified by column chromatography on silica gel
5. 5
   세척eluting with hexane

실험 절차

A solution of 2-benzyl-2,3-dihydrobenzofuran (1.9 g, 9 mmole) in 25 ml carbon tetrachloride was cooled to 0° C. and a solution of 0.46 ml (9 mmole) bromine in 5 ml carbon tetrachloride was added at 0° C. The mixture was warmed to room temperature, washed with water, sodium bicarbonate solution, and water again. The solvent was then evaporated to afford 2.5 g of crude product which was purified by column chromatography on silica gel, eluting with hexane to afford 1.0 g (38.5%) of the desired compound, m.p. 70°-72° C.

출처