반응 #343469

반응 방정식

water

4-methylphenylsulfonyl chloride

tetrahydrothiophene-3-ol

4-methylphenylsulfonyl chloride

→

product

수율 50.6%

3-Tetrahydrothienyl 4-methylphenylsulfonate

수율 50.6%

용매

pyridine

반응 조건

후처리

1. 1
   온도to warm to room temperature
2. 2
   workup.STIRRINGwas stirred for 1 hour
3. 3
   workup.STIRRINGthe reaction mixture was stirred at room temperature for 64 hours
4. 4
   추출the whole was extracted with methylene chloride
5. 5
   건조The methylene chloride solution was dried
6. 6
   농축concentrated

실험 절차

To a chilled solution of 1.12 g (0.0098 mole) of tetrahydrothiophene-3-ol in 15 mL of pyridine was added 1.91 g (0.01 mole) of 4-methylphenylsulfonyl chloride, and the reaction mixture was stirred in the cold, about 16° C., for 1 hour then placed in a cold refrigerator for 16 hours. The reaction mixture was allowed to warm to room temperature and was stirred for 1 hour. An additional 0.3 g (0.0016 mole) of 4-methylphenylsulfonyl chloride was added, and the reaction mixture was stirred at room temperature for 64 hours. The reaction mixture was poured into water, and the whole was extracted with methylene chloride. The methylene chloride solution was dried and concentrated to give 1.28 g of product as an oil.

출처