반응 #343467

반응 방정식

tetrahydro-4H-thiopyran-4-ol

4-methylphenylsulfonyl chloride

water

→

product

수율 142.0%

Tetrahydro-4H-thiopyran-4-yl 4-methylphenylsulfonate

수율 142.0%

용매

pyridine

반응 조건

후처리

1. 1
   추출the whole extracted with diethyl ether
2. 2
   세척The organic phase was washed with water
3. 3
   건조with a 10% aqueous solution of sodium hydroxide, dried
4. 4
   농축concentrated

실험 절차

To a solution of 4.1 g (0.015 mole) of tetrahydro-4H-thiopyran-4-ol in 40 mL of pyridine, cooled in an ice bath, was added 2.90 g (0.15 mole) of 4-methylphenylsulfonyl chloride, and the reaction mixture was stirred at room temperature for 16 hours. The mixture was poured into a mixture of ice and water, and the whole extracted with diethyl ether. The organic phase was washed with water then with a 10% aqueous solution of sodium hydroxide, dried, and concentrated to give 5.8 g of product as an oil.

출처