반응 #343303

반응 방정식

2-Amino-2,3-dimethylbutyramide

thieno[2,3-b]pyridine-5,6-dicarboxylic acid anhydride

N2

→

6-[(1-carbamoyl-1,2-dimethylpropyl)carbamoyl]thieno[2,3-b]pyridine-5-carboxylic acid

수율 72.0%

용매

THF

반응 조건

후처리

1. 1
   여과the resulting solid filtered off
2. 2
   세척washed with THF and air
3. 3
   기타dried

실험 절차

2-Amino-2,3-dimethylbutyramide (9.84 g, 0.076 mol) is added to a stirred suspension of thieno[2,3-b]pyridine-5,6-dicarboxylic acid anhydride (14.8 g, 0.072 mol) in THF under an inert atmosphere of N2 at room temperature. The dark solution is stirred at room temperature overnight and the resulting solid filtered off, washed with THF and air dried to give 17.35 g (72%) of 6-[(1-carbamoyl-1,2-dimethylpropyl)carbamoyl]thieno[2,3-b]pyridine-5-carboxylic acid.

출처