반응 #343003

반응 방정식

hydrochloric acid

sulfonamide

2-[5-(Methylthio)-1,3,4-oxadiazol-2-yl]benzenemethanesulfonamide

phenyl (4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamate

DBU

→

subject compound

수율 28.5%

N-[(4-Methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-[5-(methylthio)-1,3,4-oxadiazol-2-yl]benzenemethanesulfonamide

수율 28.5%

용매

water

p-dioxane

반응 조건

후처리

1. 1
   여과filtration
2. 2
   세척the residue was washed with 1×5 ml of warm ethyl acetate

실험 절차

By the procedure of Example 4, 0.62 g of the sulfonamide of Example 3 was reacted with 0.57 g of phenyl (4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamate and 0.33 g of DBU in 10 ml of p-dioxane. After stirring two hours at room temperature the solution was diluted with about 75 ml of water and acidified with concentrated hydrochloric acid (red to litmus). Following filtration, the residue was washed with 1×5 ml of warm ethyl acetate to give 0.28 g of the subject compound; m.p. 175°-177° C.

출처