반응 #3423

반응 방정식

n-BuLi

di-isopropylamine

7a-(6-Fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine

hexachloroethane

→

title compound

수율 34.0%

7a-(5-chloro-6-fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine

수율 34.0%

용매

THF

반응 조건

후처리

1. 1
   온도cooled to -78° C
2. 2
   온도The mixture was slowly warmed to room temperature
3. 3
   workup.STIRRINGstirred overnight
4. 4
   기타The reaction was quenched with 2N HCl
5. 5
   세척the mixture was washed with Et2O
6. 6
   추출extracted with methylene chloride
7. 7
   기타dried
8. 8
   농축(MgSO4) and concentrated
9. 9
   기타The residue was chromatographed (silica gel; CHCl3 /MeOH, 99:1)

실험 절차

n-BuLi (2.5M in hexanes, 0.232 mL, 0.58 mmol) was added to di-isopropylamine (0.077 mL, 0.58 mmol) in THF and stirred at room temperature for 15 minutes, then cooled to -78° C. 7a-(6-Fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine (115 mg, 0.56 mmol, from Example 12d) and hexachloroethane (400 mg, 1.7 mmol) were added. The mixture was slowly warmed to room temperature and stirred overnight. The reaction was quenched with 2N HCl, and the mixture was washed with Et2O. The aqueous layer was basified with 15% NaOH and extracted with methylene chloride. The organic extracts were combined, dried, (MgSO4) and concentrated. The residue was chromatographed (silica gel; CHCl3 /MeOH, 99:1) to afford the title compound as an oil (45 mg, 34%): 1H NMR (CDCl3, 300 MHz) δ1.60-1.72 (m, 2H), 1.80-2.06 (m, 6H), 2.64-2.72 (m, 2H), 3.14-3.27 (m, 2H), 8.00 (dd, J=8.8, 2.0 Hz, 1H), 8.15 (dd, J=2.0, 1.0 Hz, 1H); MS (CI/NH3) m/z: 241 (M+H)+.

출처