반응 #341645

반응 방정식

(E)-[1-(2,6-diethyl-phenyl)-methylidene]-(1-isopropyl-2-methyl-propyl)-amine

NaOH

→

2,6-Diethyl-benzaldehyde

용매

THF

HCl

반응 조건

후처리

1. 1
   온도to reflux for 2 hours
2. 2
   추출The aqueous phase was extracted with ethyl acetate
3. 3
   세척the combined extracts washed with brine
4. 4
   건조dried over Na2SO4
5. 5
   여과filtered
6. 6
   기타evaporated
7. 7
   기타The residue was purified by flash-chromatography on silica gel with a heptane/ethyl acetate gradient as eluent

실험 절차

A solution of 15.6 g (E)-[1-(2,6-diethyl-phenyl)-methylidene]-(1-isopropyl-2-methyl-propyl)-amine in 60 ml THF and 120 ml 4N HCl was heated to reflux for 2 hours then cooled to ambient temperature and poured onto a 1N NaOH solution. The aqueous phase was extracted with ethyl acetate, the combined extracts washed with brine, dried over Na2SO4, filtered and evaporated. The residue was purified by flash-chromatography on silica gel with a heptane/ethyl acetate gradient as eluent: 8.35 g 2,6-diethyl-benzaldehyde as light yellow oil: MS (EI): 162.1 (M+., 100%).

출처