반응 #341095

ord-473d0705b0e344ee8751b6beecf8c740

반응 방정식

CCOC(=O)C(C)Sc1cnc(NC(=O)N(C2CCCC2)[C@H]2CC[C@H](C)CC2)s1
{2-[3-Cyclopentyl-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-propionic acid ethyl ester
C[C@H]1CC[C@H](NC2CCCC2)CC1
cyclopentyl-(trans-4-methyl-cyclohexyl)-amine
CCOC(=O)C(C)S.Nc1cncs1
5-aminothiazole 2-mercaptopropionic acid ethyl ester
→
O=C(O)CCSc1cnc(NC(=O)N(C2CCCCC2)C2CCCC2)s1
title compound
O=C(O)CCSc1cnc(NC(=O)N(C2CCCCC2)C2CCCC2)s1
3-[2-(3-Cyclohexyl-3-cyclopentyl-ureido)-thiazol-5-ylsulfanyl]-propionic acid

반응물

CCOC(=O)C(C)Sc1cnc(NC(=O)N(C2CCCC2)[C@H]2CC[C@H](C)CC2)s1
{2-[3-Cyclopentyl-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-propionic acid ethyl ester
C[C@H]1CC[C@H](NC2CCCC2)CC1
cyclopentyl-(trans-4-methyl-cyclohexyl)-amine
CCOC(=O)C(C)S.Nc1cncs1
5-aminothiazole 2-mercaptopropionic acid ethyl ester

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타Hydrolysis

실험 절차

{2-[3-Cyclopentyl-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-propionic acid ethyl ester prepared as described in general procedure (A) using cyclopentyl-(trans-4-methyl-cyclohexyl)-amine and 5-aminothiazole-2-mercaptopropionic acid ethyl ester. Hydrolysis using general procedure (F) gave the title compound.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07872139B2uspto-grants-2011_01