반응 #341088

ord-08cbbc3ddc464965b6d59012f0052346

반응 방정식

CCOC(=O)CS.Nc1cncs1
5-aminothiazole 2-mercaptoacetic acid ethyl ester
CCOC(=O)CSc1cnc(NC(=O)N(C2CCCCC2)C2CCC(F)(F)CC2)s1
{2-[3-Cyclohexyl-3-(4,4-difluoro-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester
FC1(F)CCC(NC2CCCCC2)CC1
cyclohexyl-(4,4-difluoro-cyclohexyl)-amine
O=C(O)CSc1cnc(NC(=O)N(C2CCCCC2)C2CCC(F)(F)CC2)s1
title compound
O=C(O)CSc1cnc(NC(=O)N(C2CCCCC2)C2CCC(F)(F)CC2)s1
{2-[3-Cyclohexyl-3-(4,4-difluoro-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타Hydrolysis

실험 절차

{2-[3-Cyclohexyl-3-(4,4-difluoro-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester prepared using general procedures (A) and (B) using cyclohexyl-(4,4-difluoro-cyclohexyl)-amine and 5-aminothiazole-2-mercaptoacetic acid ethyl ester. Hydrolysis using general procedure (F) gave the title compound.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07872139B2uspto-grants-2011_01