반응 #341065

반응 방정식

2-Amino-5-formylthiazole

carbonyldiimidazole

cycloheptyl-(trans-4-methylcyclohexyl)amine

→

1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

수율 34.3%

용매

THF

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated
2. 2
   기타the crude product was purified by flash chromatography (silica, CH2Cl2-EtOAc, 4:1)

실험 절차

2-Amino-5-formylthiazole (2.56 g, 20.0 mmol), carbonyldiimidazole (3.25 g, 20.0 mmol) and a catalytic amount of DMAP were heated together in 60 mL THF at 50° C. for 3 h. To this solution was added cycloheptyl-(trans-4-methylcyclohexyl)amine (4.18 g, 20.0 mmol) and the reaction mixture was stirred for an additional 6 h at room temperature. The reaction mixture was concentrated and the crude product was purified by flash chromatography (silica, CH2Cl2-EtOAc, 4:1) to obtain 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (2.3 g, 31% yield).

출처