반응 #341029

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1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

1,1-dioxo-thiomorpholine hydrochloride

sodium triacetoxyborohydride

→

desired product

수율 18.0%

1,1-Dicyclohexyl-3-[5-(1,1-dioxo-thiomorpholin-4-ylmethyl)-thiazol-2-yl]-urea

수율 18.0%

반응 조건

후처리

1. 1
   기타Prepared

실험 절차

Prepared as described in general procedure (P) using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (67 mg. 0.20 mmol), 1,1-dioxo-thiomorpholine hydrochloride (52 mg, 0.30 mmol) and sodium triacetoxyborohydride (51 mg, 0.24 mmol) to afford 16 mg (18%) of the desired product after purification.

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