반응 #340363

반응 방정식

lactam

2-Benzyl-octahydro-pyrrolo[3,4-c]pyridin-4-one

LiAlH4

→

title compound

수율 102.3%

2-Benzyl-octahydro-pyrrolo[3,4-c]pyridine

수율 102.3%

용매

THF

반응 조건

후처리

1. 1
   온도cooled to 15° C.
2. 2
   기타quenched by cautious addition of water (0.15 mL)
3. 3
   여과filtered
4. 4
   세척washed with THF (3×5 mL)
5. 5
   농축The filtrate was concentrated in vacuo

실험 절차

To a solution of the lactam from Example 22C (0.46 g) in THF (5 mL) was added 1M LiAlH4 (4.0 mL). The mixture was heated at 50° C. for 2 h, cooled to 15° C., and quenched by cautious addition of water (0.15 mL), followed by 15% NaOH (0.15 mL), then water (0.456 mL). The mixture was stirred for 5 minutes and filtered and washed with THF (3×5 mL). The filtrate was concentrated in vacuo to afford 442 mg of the title compound as a clear oil (quantitative yield). MS (CI) m/z 217 (M+H)+; 1H NMR: δ 1.8-1.5 (m, 3H), 2.33-2.10 (m, 2H), 2.8-2.4 (m, 8H), 3.75 (s, 2H), 7.25 ppm (m, 5H).

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