반응 #339624

반응 방정식

5-cyano-6-(2-nitro-5-phenoxy-phenyl)-4-(tetrahydro-pyran-4-yl)-hex-5-enoic acid

N-methylcyclohexylamine

HBTU

DIPEA

→

title compound

5-Cyano-6-(2-nitro-5-phenoxy-phenyl)-4-(tetrahydro-pyran-4-yl)-hex-5-enoic acid cyclohexyl-methyl-amide

용매

Ethyl acetate

DMF

반응 조건

후처리

1. 1
   세척The solution was washed with saturated aqueous NaHCO3 solution
2. 2
   기타The organic phase was separated
3. 3
   건조dried with MgSO4
4. 4
   여과filtered
5. 5
   기타The solvent was removed in vacuo

실험 절차

A solution of 5-cyano-6-(2-nitro-5-phenoxy-phenyl)-4-(tetrahydro-pyran-4-yl)-hex-5-enoic acid (0.87 g, 2 mmol), N-methylcyclohexylamine (0.26 mL, 2 mmol), HBTU (1.13 g, 3 mmol), DIPEA (1.2 mL, 7 mmol) in DMF (20 mL) was stirred at room temperature overnight. Ethyl acetate was added to the reaction mixture. The solution was washed with saturated aqueous NaHCO3 solution. The organic phase was separated and dried with MgSO4, and filtered. The solvent was removed in vacuo to yield the title compound as an oil.

출처