반응 #338952

반응 방정식

aluminum chloride

1,2-dichloroethane

acetyl chloride

4-bromo biphenyl

1,2-dichloroethane

→

1-(4′-bromo-biphenyl-4-yl)-ethanone

수율 102.1%

용매

water

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   온도while cooling with ice
3. 3
   온도while cooling with ice for 4 hours
4. 4
   기타After completion of the reaction
5. 5
   추출an extraction
6. 6
   세척Further, washing with water
7. 7
   건조dried with the use of sodium sulfate
8. 8
   기타Removing the solvent
9. 9
   workup.DISTILLATIONby distillation

실험 절차

Four point three grams (32 mmol) of aluminum chloride was placed into 30 milliliter of 1,2-dichloroethane and a solution made by dissolving 2.0 g (25 mmol) of acetyl chloride, subsequently 5.0 g (21 mmol) of 4-bromo biphenyl into 20 milliliter of 1,2-dichloroethane was added while cooling with ice. The mixed solution was stirred as it is while cooling with ice for 4 hours. After completion of the reaction, adding water and an extraction was carried out using dichloro-methane. Further, washing with water, dried with the use of sodium sulfate. Removing the solvent by distillation, 5.9 g of crude 1-(4′-bromo-biphenyl-4-yl)-ethanone was obtained.

출처