반응 #338603

반응 방정식

piperazine

6-chloro-2,4-dimethoxy pyrimidine

→

required compound

2,4-dimethoxy-6-piperazin-1-ylpyrimidine

용매

acetonitrile

반응 조건

후처리

1. 1
   workup.ADDITIONSubsequently the reaction mixture was poured onto ice-cold water (25 ml)
2. 2
   추출extracted with ethyl acetate (25 ml)
3. 3
   세척The organic layer was washed with aqueous sodium bicarbonate solution
4. 4
   기타evaporated

실험 절차

piperazine (1.23 g, 14.32 mmol) was treated with 6-chloro-2,4-dimethoxy pyrimidine (0.5 g, 2.86 mmol) in acetonitrile (5 mL) and the reaction mixture was stirred at room temperature for 6 hours. Subsequently the reaction mixture was poured onto ice-cold water (25 ml) and extracted with ethyl acetate (25 ml). The organic layer was washed with aqueous sodium bicarbonate solution and evaporated to furnish the required compound.

출처