반응 #337837

반응 방정식

diisopropyl azodicarboxylate

4-Hydroxy-3-methoxybenzaldehyde

4-hydroxy-3-methoxybenzaldehyde

triphenylphosphine

4-Chlorophenylmethylcarbinol

4-chlorophenylmethylcarbinol

→

desired compound

4-[1-(4-chloro-phenyl)-ethoxy]-3-methoxy-benzaldehyde

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타purified by silica gel chromatography, ethyl acetate

실험 절차

4-Chlorophenylmethylcarbinol (643, 0.668 mL, 6.57 mmol) was dissolved in tetrahydrofuran (60.0 mL) at 0° C. under an atmosphere of nitrogen. 4-Hydroxy-3-methoxybenzaldehyde (105, 1.00 g, 6.57 mmol) and triphenylphosphine (2.07 g, 7.89 mmol) were added to the reaction, followed by diisopropyl azodicarboxylate (1.55 mL, 7.89 mmol) over 10 minutes. The reaction was stirred for 2 hours. The mixture was adsorbed onto silica and purified by silica gel chromatography, ethyl acetate:hexanes, to provide the desired compound, (644, 1.14 g, 60%). 1H-NMR was consistent with the desired compound.

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