반응 #337664

반응 방정식

sodium methoxide

4-dimethylcarbamoylsulfanyl-7-phenoxy-isoquinoline-3-carboxylic acid butyl ester

→

product

수율 91.0%

4-Mercapto-7-phenoxy-isoquinoline-3-carboxylic acid methyl ester

수율 91.0%

용매

water

HCl

methanol

반응 조건

후처리

1. 1
   기타The resulting yellow precipitate was collected
2. 2
   여과by filtering the solution through a (medium) porous buchner
3. 3
   여과filter funnel

실험 절차

To a solution of 6.5 ml of 0.5 N sodium methoxide in methanol was added 460 mg of 4-dimethylcarbamoylsulfanyl-7-phenoxy-isoquinoline-3-carboxylic acid butyl ester. The resultant solution was heated to 50-60° C. for 8 hours, cooled to room temperature, and diluted with 10 ml water and 7.0 ml 1 N HCl. The resulting yellow precipitate was collected by filtering the solution through a (medium) porous buchner filter funnel to give 307 mg of product; MS (+) m/z 312.08 (M+1)

출처