반응 #3375

반응 방정식

4-mercapto-2-piperidin-1-yl-pyrimidine-5-carboxylic acid amide

iodine

→

title compound

수율 69.6%

6-Piperidin-1-yl-isothiazolo[5,4-d]pyrimidin-3-one

수율 69.6%

반응 조건

실험 절차

Using the procedure of Example 20, 20.8 g (87.4 mmol) of 4-mercapto-2-piperidin-1-yl-pyrimidine-5-carboxylic acid amide were treated with 22.2 g (87.4 mmol) of iodine to give 14.37 g of the title compound after recrystallization from dimethylformamide, mp 268°-269° C.

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