반응 #337116

반응 방정식

2-Amino-4-methoxybenzonitrile

bromine

diethyl ether

→

desired product

수율 81.0%

2-Amino-5-bromo-4-methoxybenzonitrile

수율 81.0%

용매

dioxane

반응 조건

후처리

1. 1
   여과the resulting crystals are filtered off with suction

실험 절차

2-Amino-4-methoxybenzonitrile (4.47 g, 30.2 mmol) is dissolved in 70 ml of dioxane and treated at 0° C. with bromine (1.71 ml, 33.2 mmol). It is subsequently stirred at 0° C. for one hour. After addition of diethyl ether, the resulting crystals are filtered off with suction. The desired product is obtained in 81% yield (5.52 g).

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