반응 #336514

반응 방정식

Octyl chloroformate

2-(2-aminophenyl)-2,3-dihydro-1H-indole

pyridine

→

solid

2-[2-(Octyloxycarbonylamino)phenyl]-2,3-dihydro-1H-indole

용매

CH2Cl2

반응 조건

후처리

1. 1
   기타quenched with water
2. 2
   기타The organic layer was separated
3. 3
   세척washed with 5% HCl and saturated NaCl solution
4. 4
   건조dried (MgSO4)
5. 5
   농축concentrated
6. 6
   기타to yield a solid
7. 7
   기타Purification by flash chromatography

실험 절차

Octyl chloroformate (2.00 ml) was added dropwise to a solution of 2.15 g 2-(2-aminophenyl)-2,3-dihydro-1H-indole and 2.00 ml pyridine in 35 ml CH2Cl2 at 0° C. The solution was stirred five hours at 0° C. and then quenched with water. The organic layer was separated, washed with 5% HCl and saturated NaCl solution, dried (MgSO4), and concentrated to yield a solid. Purification by flash chromatography using CH2Cl2 /hexane (1:2) as eluent gave 1.74 g solid, m.p. 99°-102° C.

출처