반응 #3365

반응 방정식

2-amino-4-methylpyridine

2-chlorosulfenylbenzoyl chloride

→

title compound

수율 37.1%

2-(4-Methylpyridin-2-yl)-3-oxo-3h-benzo[d]isothiazole

수율 37.1%

용매

pyridine

반응 조건

후처리

1. 1
   기타at 10° C.
2. 2
   온도maintained at that temperature for 2 hours
3. 3
   온도The mixture was cooled to 25° C.
4. 4
   여과filtered
5. 5
   기타The solid was recrystallized from benzene

실험 절차

Using the method of Fischer and Hurni (Arzneimittel Forsch., 1964;14:1301) 5.4 g (0.05 mol) of 2-amino-4-methylpyridine in 50 mL of pyridine at 10° C. was reacted with 10.3 g (0.05 mol) of 2-chlorosulfenylbenzoyl chloride. The mixture was heated to 50° C. and maintained at that temperature for 2 hours. The mixture was cooled to 25° C. and filtered. The solid was recrystallized from benzene to give 4.5 g of the title compound, mp 195°-196.5° C.

출처