반응 #336026

반응 방정식

((1R,3R,4S)-1-methyl-4-isopropylcyclohex-3-yloxy)acetic acid

N,N,N'-triethylethylenediamine

dicyclohexylcarbodiimide

→

N-(2- diethylaminoethyl)-N-(ethyl)-((1R,3R,4S)-1-methyl-4-isopropylcyclohex-3-yloxy)acetamide

수율 60.4%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   농축by concentrating it under reduced pressure
2. 2
   기타The remaining residue was purified by chromatography on silica gel

실험 절차

5.0 g of ((1R,3R,4S)-1-methyl-4-isopropylcyclohex-3-yloxy)acetic acid were dissolved in 100 ml of tetrahydrofuran. 3.4 g (=4.2 ml) of N,N,N'-triethylethylenediamine and 5.3 g of dicyclohexylcarbodiimide were added to the solution, and the reaction mixture was stirred at room temperature for 24 hours. The mixture was worked up by concentrating it under reduced pressure. The remaining residue was purified by chromatography on silica gel using dichloromethane/methanol as the eluent. 4.8 g of N-(2- diethylaminoethyl)-N-(ethyl)-((1R,3R,4S)-1-methyl-4-isopropylcyclohex-3-yloxy)acetamide were obtained.

출처