반응 #335949

반응 방정식

potassium carbonate

1,2,4-triazole

3,4-dihydro-2-bromo-1(2H)-naphthalenone

→

product

3,4-Dihydro-2-(1H-1,2,4-triazole-1-yl)-1(2H)-Naphthalenone

용매

acetonitrile

dichloromethane

acetonitrile

반응 조건

후처리

1. 1
   workup.ADDITIONTo a mixture of 30 g
2. 2
   기타to react for 5 hours at 40° C.
3. 3
   온도than at reflux temperature for 2 hours
4. 4
   기타The solid was removed by filtration
5. 5
   농축the filtrate concentrated to dryness
6. 6
   기타leaving a solid residue
7. 7
   세척washed twice with water
8. 8
   추출The organic extract
9. 9
   건조was dried over sodium sulfate
10. 10
    기타evaporated

실험 절차

To a mixture of 30 g. potassium carbonate, 15 g. 1,2,4-triazole and 250 ml acetonitrile at 40° C. was added a solution of 45 g. 3,4-dihydro-2-bromo-1(2H)-naphthalenone in 150 ml acetonitrile. The mixture was allowed to react for 5 hours at 40° C. and than at reflux temperature for 2 hours. The solid was removed by filtration and the filtrate concentrated to dryness leaving a solid residue. This was dissolved in dichloromethane and washed twice with water. The organic extract was dried over sodium sulfate and evaporated to give 42 grams of product having a melting point of 96°-98° C.

출처