반응 #335923

반응 방정식

3-[N-(4-fluoro-2-trifluoromethylphenyl)sulfamoyl]propionic acid

L-alanine ethyl ester hydrochloride

hydroxybenzotriazole, hydrate

triethylamine

dicyclohexylcarbodiimide

→

2-[3-[N-(4-Fluoro-2-trifluoromethylphenyl)sulfamoyl]propionylamino]-2-methylacetic Acid Ethyl Ester

반응 조건

후처리

1. 1
   기타The crude product is purified by column chromatography on silica gel
2. 2
   세척The title compound is eluted with ethyl acetate

실험 절차

Under the conditions of Example 2(a), 3.152 g (10 mmol) of 3-[N-(4-fluoro-2-trifluoromethylphenyl)sulfamoyl]propionic acid, 1.536 g (10 mmol) of L-alanine ethyl ester hydrochloride, 1.531 g (10 mmol) of hydroxybenzotriazole, hydrate, as well as 1.012 g (10 mmol) of triethylamine and 2.063 g (10 mmol) of dicyclohexylcarbodiimide are reacted and worked up analogously. The crude product is purified by column chromatography on silica gel. The title compound is eluted with ethyl acetate.

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