반응 #335897

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2-[N-(4-Fluoro-2-trifluoromethylphenyl)sulfamoyl]acetic acid

L-alanine ethyl ester hydrochloride

hydroxybenzotriazole, hydrate

triethylamine

→

2-[2-[N-(4-Fluoro-2-trifluoromethylphenyl)sulfamoyl]acetylamino]-2-methylacetic Acid Ethyl Ester

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후처리

1. 1
   기타The crude product is chromatographed on silica gel
2. 2
   세척The title compound is eluted with ethyl acetate

실험 절차

Under the conditions of Example 2(a), 3.012 g (10 mmol) of 2-[2-[N-(4-Fluoro-2-trifluoromethylphenyl)sulfamoyl]acetic acid, 1.536 g (10 mmol) of L-alanine ethyl ester hydrochloride, 1.531 g (10 mmol) of hydroxybenzotriazole, hydrate, as well as 1.012 g (10 mmol) of triethylamine are reacted and worked up in analogous fashion. The crude product is chromatographed on silica gel. The title compound is eluted with ethyl acetate.

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